Projects completed in 2014

An interactive gateway for relaying physiological parameters and video data between mobile ambulances and hospitals (AMBULET)

Principal Investigator
Dr Malati Hegde (Principal Scientific Officer, Department of Electrical Communication Engineering)

Duration
1 July 2013 to 30 June 2014

“AMBULET” is an interactive gateway for relaying physiological parameters and video data between mobile ambulances and the health practitioners/hospitals. Nearly 51% of accident–related deaths occur due to inadequate medical attention during transportation to the hospital. AMBULET supports multiple streams of multiplexed real-time data transport using associated application proxies over a set of bonded channels to transparently and dynamically maintain desired levels of service quality over the cellular communications infrastructure.

Project Publications

1.

Kumaresh, D; Suhas, N; Krishna, Garge Gopi S; Anand, S V R; Hedge, Malati

SeaMoX: A seamless mobility management scheme for real-time multimedia traffic over cellular networks Conference

Proceedings of 2nd International Symposium on Signal Processing and Intelligent Recognition Systems (SIRS), India, Advances in Intelligent Systems and Computing 2015.

Abstract | BibTeX | Links:


Development of a smart-camera based optofluidic microscope for Malaria detection

Principal Investigator
Prof Sai Siva Gorthi (Assistant Professor, Department of Instrumentation and Applied Physics)

Duration
1 July 2013 to 30 June 2014

In this project, we developed an “imaging” based point-of-care diagnostic device, which can fully-automate the complete work flow of conventional clinical microscopy. A custom designed portable digital microscope augmented with dedicated microfluidic lab-on-chips enables process automation, as well as, cost effective implementation of microscopic diagnosis of malaria. Such an inexpensive, portable and easy-to-use diagnostic device, which requires minimal skilled human intervention, greatly enhances the quality of health-care available to the rural population of the world.

Project Publications

1.

Jagannadh, Veerendra Kalyan; Srinivasan, Rajesh; Gorthi, Sai Siva

A semi-automated, field-portable microscopy platform for clinical diagnostic applications Journal Article

AIP Advances, 5 (8), 2015.

Abstract | BibTeX | Links:

2.

Jagannadh, Veerendra Kalyan; Adhikari, Jayesh Vasudeva; Gorthi, Sai Siva

Automated cell viability assessment using a microfluidics based portable imaging flow analyzer Journal Article

AIP Biomicrofluids, 9 (2), 2015.

Abstract | BibTeX | Links:

3.

Jagannadh, Veerendra Kalyan; Murthy, Rashmi Sreeramachandra; Srinivasan, Rajesh; Gorthi, Sai Siva

Automated quantitative cytological analysis using portable microfluidic microscopy Journal Article

Journal of Biophotonics, 9 (6), pp. 586-595, 2015.

Abstract | BibTeX | Links:

4.

Jagannadh, Veerendra Kalyan; Murthy, Rashmi Sreeramachandra; Srinivasan, Rajesh; Gorthi, Sai Siva

Field-portable microfluidics-dased imaging flow cytometer Journal Article

Journal of Lightwave Technology, 33 (16), pp. 3469-3474, 2015.

Abstract | BibTeX | Links:

5.

Jagannadh, Veerendra Kalyan; Mackenzie, Mark D; Pal, Parama; Kar, Ajoy K; Gorthi, Sai Siva

Imaging flow cytometry with femtosecond laser-micromachined glass microfluidic channels Journal Article

IEEE Journal of Selected Topics in Quantum Electronics, 21 (4), 2015.

Abstract | BibTeX | Links:

6.

Jagannadh, Veerendra Kalyan; Mackenzie, Mark D; Pal, Parama; Kar, Ajoy K; Gorthi, Sai Siva

Optofluidic microscopy using femtosecond micromachined glass microfluidics Conference

Proceedings of the 12th International Conference on Fibre Optics and Photonics, India, 2014.

Abstract | BibTeX | Links:

Patent Applications

  1. Gorthi, Sai Siva; Jagammadh, Veerendra Kalyan
    A microscopy system and method for analysing fluids
    Indian Patent Application No. 2432/CHE/2014 (15.01.16)
    PCT Application No. PCT/IB2015/053581
  2. Gorthi, Sai Siva; Daniel, S. C. G. Kiruba; Nirupa, L. Albina
    Microfludics based on-chip biosynthesis of metal nanoparticles at room temperature
    Indian Patent Application No. 3649/CHE/2015 (20.01.17)
  3. Gorthi, Sai Siva
    A real-time sample classifier
    Indian Patent Application No. 4110/CHE/2015
  4. Gorthi, Sai Siva
    A microfluidic cartridge
    Indian Patent Application No. 4229/CHE/2015
  5. Gorthi, Sai Siva; Daniel, S. C. G. Kiruba; Nirupa, L. Albina
    Real-time sensing of analytes by on-chip interference-synthesis of noble metal nanoparticles
    Indian Patent Application No. 4882/CHE/2015

Low-cost, efficient and portable blood cell counter for point-of-care diagnostics

Principal Investigator
Prof V. Kumaran (Professor, Department of Chemical Engineering)

Duration
1 September 2013 to 31 August 2014

This project addressed two critical technologies for performing complete blood counts for health diagnostics. The technologies include the rapid mixing of samples and reagents in channels of small dimensions and impedance measurements across these channels to measure and characterize the cells flowing through them. The process workflow is completely automated (liquid injection, mixing and handling processes such as lysing and quenching) and novel approaches have been adopted to fabricate miniature (less than a hundred microns) electrodes in the walls of the channels. This technology is currently being spun-off as a startup (MicroX Labs).


Smart phone interferometer

Principal Investigator
Prof Manoj Varma (Associate Professor, Centre for Nano Science and Engineering)

Duration
1 April 2013 to 31 March 2014

A micro-diffractive structure patterned on a thin film surface enables the differential read-out of phase and amplitude change caused due to the molecular adsorption on the surface with a limit of detection as low as 3×10-6 RIU (refractive index units equivalent to an optical thickness of about 10 picometers) comparable to dominant techniques such as Surface Plasmon Resonance (SPR). This technique also allows the measurement of molecular binding kinetics similar to SPR.

Our implementation was based on transmission mode measurements and therefore enabled the use of low cost CMOS imagers, e.g. mobile phone cameras, to be used for interferometric measurements of molecular adsorption or refractive index changes. Such devices are very beneficial for low cost point-of-care diagnostics among other applications. Interferometry is one of the most sensitive metrological technique available today and is being used to detect gravitational waves (LIGO project), which are one of the weakest phenomena known to mankind.

Implementing interferometry using our micro-fabricated devices attached on top of the camera of a smart phone was the first demonstration of the mobile phone as a sophisticated metrological tool. Our microfabricated device consists of photolithographically patterned glass surface consisting of microarrays of a specified depth designed to maximize the interferometric contrast. Any small refractive index (or thickness) perturbation on this device can be measured as a change in diffraction pattern which is captured by the mobile phone camera. As pointed earlier, this interferometric technique is comparable to existing optical bio-detection techniques such as SPR.

Project Publications

1.

Sasikumar, Harish; Prasad, Vishnu; Pal, Parama; Varma, Manoj

Diffractive interference optical analyzer (DiOPTER) Conference

Proceedings of the 2016 SPIE International Conference Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 13.02.16, San Francisco (USA), 9715 , 2016.

Abstract | BibTeX | Links:

2.

Pal, Parama; Sasikumar, Harish; Varma, Manoj

Label-free biosensing using diffractive optical analysis Conference

Proceedings of the 13th International Conference on Fiber Optics and Photonics, 04.-06.12.16, Kanpur (India), 2016.

Abstract | BibTeX | Links: